SmartKem, Inc.

SmartKem, Inc. (the “Company”) is unable to file its Quarterly Report on Form 10-Q for the quarter ended March 31, 2026 (the “Report”) within the prescribed time period without unreasonable effort and expense. The Company currently expects to file the Report by May 20, 2026, within the extension period of five calendar days permitted under Rule 12b-25 of the Securities Exchange Act of 1934, as amended. SEC 1344 (04-09) Persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number

SmartKem, Inc. (the “Company”) is unable to file its Annual Report on Form 10-K for the fiscal year ended December 31, 2025 (the “Annual Report”) within the prescribed time period without unreasonable effort and expense. The Company currently expects to file the Annual Report by April 15, 2025, within the extension period of fifteen calendar days permitted under Rule 12b-25 of the Securities Exchange Act of 1934, as amended

SmartKem, Inc. (the “Company”) is unable to file its Quarterly Report Form 10-Q for the three months ended March 31, 2024 (the “Form 10-Q”) within the prescribed time period due to a delay in obtaining and compiling information required to be included in the Form 10-Q. In particular, the Company entered into a Consent, Conversion and Amendment Agreement on January 26, 2024, as described in the Company’s Current Report on Form 8-K filed with the U.S. Securities and Exchange Commission (the “SEC”) on January 29, 2024, and certain valuation work associated with the agreement could not be completed in order to file the Form 10-Q by the required due date of May 15, 2024. The Company intends to file the Form 10-Q with the SEC on or before May 20, 2024 (the extended deadline prescribed by Rule 12b-25)

SmartKem, Inc. (the “Company”) is unable to file its Quarterly Report on Form 10-Q for the period ended June 30, 2022 by the prescribed due date without unreasonable effort or expense because of the circumstances described below. As reported in the Company’s Item 4.02 Current Report on Form 8-K filed on August 15, 2022, the Audit Committee (the “Audit Committee”) of the Board of Directors of the Company concluded, after discussion with the Company’s management, that the Company’s financial statements inaccurately presented unrealized gains and losses from changes in exchange rates in its consolidated statements of cash flows and, as of and for the quarterly and annual periods ended from March 31, 2021 through March 31, 2022 (collectively, the “Non-Reliance Periods”) included in the associated 10-K for the fiscal year ended December 31, 2021, Form 10-Qs for the periods ended March 31, 2021, June 30, 2021, September 30, 2021 and March 31, 2022, filed with the Securities Exchange Commission (the “SEC”), (1) should no longer be relied upon due to errors in the presentation of gains and losses from changes in exchange rates in the consolidated statements of cash flows, and (2) will require restatement. As a result, the Company will file amendments to its Form 10-K for the fiscal year ended December 31, 2021 and to its Form 10-Qs for the periods ended September 30, 2021 and March 31, 2022 (including comparative information for March 31, 2021) to restate the previously issued financial statements, with restated comparatives for June 30, 2021 also restated in the Form 10-Q for the period ended June 30, 2022. The Company expects to file with the SEC such amendments on or prior to August 22, 2022, which is the first business day following the fifth calendar day after the prescribed due date for the Company’s Quarterly Report on Form 10-Q (the “Quarterly Report”) for the quarter ended June 30, 2022